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International Journal of Engineering Business Management, Vol.6 No.Godište 2014 January 2014. -

This work aims to assess the impact of maintenance-oriented design on a production line in the pharmaceutical industry, which includes operations in a clean room. The case study analyses the downtimes of a production line of large volume parental solutions. The results obtained at the end of an appropriate period of observation were used to identify the main problems, in terms of maintenance time. Some of the critical issues were overcome by requiring that part of the production line be redesigned by a company specialized in the design of clean room lines. In this context, the focus of the case study is not on the technical aspects of maintenance-oriented design application, but its consequences in terms of the increase in performance. The performance of the new production line was analysed and compared with that obtained in the first phase of the study. This comparison allowed us to estimate and quantify the achieved improvements referring to system availability and consequently to a production increase quantified at more than 110,000 units. The impact of the maintenance-oriented design was also evaluated from an economic point of view. In particular,the production increase obtained and the corresponding economic advantages were evaluated. Through this comparison, it was possible to estimate the payback period for the investment of redesign, quantified in less than six years.

Pharmaceutical; Redesign; Availability; Reengineering; TPM



Autor: Vincenzo Duraccio - ; University Niccolò Cusano,Rome Antonio Forcina - ; University of Cassino and Southern Lazio Alessandro Sil

Fuente: http://hrcak.srce.hr/



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