Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic BoundariesReportar como inadecuado




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Background

Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder BD. After finding a linkage between the ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene locus 15q26 and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.

Methods

A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms SNPs across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.

Results

Fourteen of 34 SNPs showed a nominally significant association p < 0.05 with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder BD-I groups. The strongest association was observed in rs11637898 for schizophrenia p = 0.0033 and BD-I p = 0.0050 under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group p = 0.0006, under the dominant model remained significant after correcting for multiple testing.

Discussion

We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.



Autor: So Yung Yang, Ik Soo Huh, Ji Hyun Baek, Eun-Young Cho, Mi Ji Choi, Seunghyong Ryu, Ji Sun Kim, Taesung Park, Kyooseob Ha, Kyung S

Fuente: http://plos.srce.hr/



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