Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult PopulationReportar como inadecuado

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Prehypertension is associated with cardiovascular disease CVD. There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression from normotension to prehypertension in a Middle East population-based cohort, during a median follow-up of 9.2 years.


A multivariate Cox analysis was performed among 1466 and 2131 Iranian men and women, respectively, who were free of prehypertension, hypertension, CVD and diabetes at baseline and free of incident hypertension without preceding prehypertension at follow-up. Incident prehypertension at follow-up was defined as systolic blood pressure SBP of 120–139 mmHg and-or diastolic blood pressure DBP of 80–89 mmHg.


Overall, 1440 new cases of prehypertension were identified resulting in an incidence rate of 593-10000 person-years; the corresponding values for women and men were 489-10000 and 764-10000person-years, respectively. There were significant interactions between gender with age, DBP, waist-to-hip-ratio WHpR and estimated glomerular filtration rate eGFR all P-values <0.05 in multivariate analysis. Strong associations were found between age, body mass index BMI and SBP with incident prehypertension in both genders. However, the effect of DBP and WHpR was significant among women and 2-hour post challenge plasma glucose 2h-PCPGwas an independent risk factor for men. In the sex-adjusted analysis, glomerular hyperfiltration Hazard ratio HR and 95%CI: 1.01 1.00–1.01, P-value = 0.02, age, BMI, WHpR, SBP and DBP had higher risks while being female HR 95%CI: 0.810.69–0.94, P-value = 0.01 had a lower risk for incident prehypertension.


According to this study results, among Iranian population with high incidence of prehypertension, general adiposity and glomerular hyperfiltration in total, 2h-PCPG in men and central adiposity in women should be emphasized as risk factors for prehypertension.

Autor: Farzad Hadaegh , Mitra Hasheminia , Hengameh Abdi , Davood Khalili, Mohammadreza Bozorgmanesh, Banafsheh Arshi, Fereidoun Azizi



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