Genetic Variation in the 3-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese PopulationReportar como inadecuado




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NBN plays a crucial role in carcinogenesis as a core component for both homologous recombination HR and non-homologous end-joining NHEJ DNA double-strand breaks DSBs repair pathways. Genetic variants in the NBN gene have been associated with multiple cancers risk, suggesting pleiotropic effect on cancer. We hypothesized that genetic variants in the NBN gene may modify the risk of gastric cancer. To test this hypothesis, we evaluated the association between four potentially functional single nucleotide polymorphisms in NBN and gastric cancer risk in a case–control study of 1,140 gastric cancer cases and 1,547 controls in a Chinese population. We found that the A allele of rs10464867 G>A was significantly associated with a decreased risk of gastric cancer odds ratio OR = 0.81, 95% confidence interval 95% CI = 0.71–0.94; P = 4.71×10−3. Furthermore, the association between A allele of rs10464867 and decreased risk of gastric cancer was more significantly in elder individuals per-allele OR = 0.720.59–0.88, P = 1.07×10−3, and male individuals per-allele OR = 0.730.62–0.87, P = 3.68×10−4. We further conducted a haplotype analysis and identified that the NBN Ars10464867Grs14448Grs1063053 haplotype conferred stronger protective effect on gastric cancer OR = 0.760.65–0.89, P = 6.39×10−4. In summary, these findings indicate that genetic variants at NBN gene may contribute to gastric cancer susceptibility and may further advance our understanding of NBN gene in cancer development.



Autor: Ping Sun , Jiangbo Du , Xun Zhu, Chuanli Ren, Lan Xie, Ningbin Dai, Yayun Gu, Caiwang Yan, Juncheng Dai, Hongxia Ma, Yue Jiang, J

Fuente: http://plos.srce.hr/



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