Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed ShrewsReportar como inadecuado

Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.


Many RNA viruses arise from animal reservoirs, namely bats, rodents and insectivores but mechanisms of virus maintenance and transmission still need to be addressed. The bicolored white-toothed shrew Crocidura leucodon has recently been identified as reservoir of the neurotropic Borna disease virus 1 BoDV-1.

Principal Findings

Six out of eleven wild living bicoloured white-toothed shrews were trapped and revealed to be naturally infected with BoDV-1. All shrews were monitored in captivity in a long-term study over a time period up to 600 days that differed between the individual shrews. Interestingly, all six animals showed an asymptomatic course of infection despite virus shedding via various routes indicating a highly adapted host-pathogen interaction. Infectious virus and viral RNA were demonstrated in saliva, urine, skin swabs, lacrimal fluid and faeces, both during the first 8 weeks of the investigation period and for long time shedding after more than 250 days in captivity.


The various ways of shedding ensure successful virus maintenance in the reservoir population but also transmission to accidental hosts such as horses and sheep. Naturally BoDV-1-infected living shrews serve as excellent tool to unravel host and pathogen factors responsible for persistent viral co-existence in reservoir species while maintaining their physiological integrity despite high viral load in many organ systems.

Autor: Daniel Nobach, Manon Bourg, Sibylle Herzog, Hildburg Lange-Herbst, Jorge A. Encarnação, Markus Eickmann, Christiane Herden



Documentos relacionados