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Surgical site infections SSIs are a major threat for liver transplant recipients. We prospectively studied SSIs after living donor liver transplantation LDLT at Kyoto University Hospital from April 2001 to March 2002 1st period and from January 2011 to June 2012 2nd period. We investigated the epidemiology of SSIs after LDLT and determined the differences between the two periods. A total of 129 adult recipients 66 during the 1st period and 63 during the 2nd period and 72 pediatric recipients 39 and 33 were included in this study. The SSI rates for each period were 30.3% 1st period and 41.3% 2nd period among the adult recipients and 25.6% and 30.3% among the pediatric recipients. The overall rates of 30-day mortality among adult transplant recipients with SSIs were 10.0% 1st period and 3.9% 2nd period. No pediatric recipient died from SSIs after LDLT in either period. The incidence of Enterococcus faecium increased from 5.0% to 26.9% in the adults and from 10.0% to 40.0% in the pediatric patients. Extended-spectrum β-lactamase-producing Enterobacteriaceae were emerging important isolates during the 2nd period. For this period, a univariate analysis showed that ABO incompatibility P = 0.02, total operation duration P = 0.01, graft-to-recipient body weight ratio GRWR P = 0.04, and Roux-en-Y biliary reconstruction P<0.01 in the adults and age P = 0.01 and NHSN risk index P = 0.02 in the children were associated with SSI development. In a multivariate analysis, lower GRWR P = 0.02 and Roux-en-Y biliary reconstruction P<0.01 in the adults and older age P = 0.01 in the children were independent risk factors for SSIs during the 2nd period. In conclusion, SSIs caused by antibiotic resistant bacteria may become a major concern. Lower GRWR and Roux-en-Y biliary reconstruction among adult LDLT recipients and older age among pediatric LDLT recipients increased the risk of developing SSIs after LDLT.

Autor: Masaki Yamamoto, Shunji Takakura , Yoshitsugu Iinuma, Go Hotta, Yasufumi Matsumura, Aki Matsushima, Miki Nagao, Kohei Ogawa, Yasu



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