Effect of Paternal Age on Reproductive Outcomes of In Vitro FertilizationReportar como inadecuado

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Although the adverse effects of maternal aging on reproductive outcomes have been investigated widely, there is no consensus on the impact of paternal age. Therefore, we investigated the effect of paternal age on reproductive outcomes in a retrospective analysis of 9,991 in vitro fertilization IVF cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Guangzhou Medical University China between January 2007 and October 2013. Samples were grouped according to maternal age <30 3,327 cycles, 30–34 4,587 cycles, and 35–38 2,077 cycles and then subgrouped according to paternal age <30, 30–32, 33–35, 36–38, 39–41, and ≥42. The groups did not differ in terms of fertilization rate, numbers of viable and high-quality embryos and miscarriage rate when controlling maternal age P >0.05. Chi-squared analysis revealed that there were no differences in implantation and pregnancy rates among the different paternal age groups when maternal age was <30 and 35–38 years P >0.05. However, implantation and pregnancy rates decreased with paternal age in the 31–34 y maternal age group P <0.05. Our study indicates that paternal age has no impact on fertilization rate, embryo quality at the cleavage stage and miscarriage rate. For the 30–34 y maternal age group, the implantation rate decreased with increased paternal age, with the pregnancy rate in this group being significantly higher in the paternal <30 y and 30–32 y age groups, compared with those in the 36–38 y and 39–41 y groups.

Autor: Yixuan Wu , Xiangjin Kang , Haiyan Zheng, Haiying Liu, Jianqiao Liu

Fuente: http://plos.srce.hr/


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