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ADMET and DMPK, Vol.4 No.1 March 2016. -

A reversed phase parallel artificial membrane permeation assay RP-PAMPA was newly invented for log P measurement. An oil-water-oil sandwich was constructed using a conventional PAMPA instrument. 1 % agarose was used to improve the physical stability of the water phase. A linear correlation between log P and the apparent permeability was observed in the -0.24 < log P < 2.85 region R2 = 0.98. RP-PAMPA was also applied to pKa measurement.

octanol; partition; parallel artificial membrane permeation assay; pKa; drug



Autor: Zihao Song - ; Department of pharmaceutics, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba,

Fuente: http://hrcak.srce.hr/



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