CD24 and APC Genetic Polymorphisms in Pancreatic Cancers as Potential Biomarkers for Clinical OutcomeReportar como inadecuado




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Background

There are no validated biomarkers that correlate with the prognosis of pancreatic ductal adenocarcinoma PDA. The CD24 and adenomatous polyposis coli APC genes are important in the malignant transformation of gastrointestinal cells. This study examined APC and CD24 genetic polymorphisms and their possible impact on survival of patients with PDA.

Methods

Clinical and pathological data as well as blood samples for extracting DNA were obtained for 73 patients with PDA. Real-time PCR assessed genetic variants of APC I1307K and E1317Q, and four different single nucleotide polymorphisms SNPs in the CD24 gene: C170T rs52812045, TG1527del rs3838646, A1626G rs1058881 and A1056G rs1058818.

Results

The median age at diagnosis was 64 41–90 years. Thirty-one patients 42.5% were operable, 16 22% had locally advanced disease and 26 35.5% had disseminated metastatic cancer. The malignancy-related mortality rate was 84%. Median survival was 14 months 11.25–16.74. Survival was similar for wild-type WT, heterozygous and homozygous variants of the APC or CD24 genes. The three most frequent CD24 SNP combinations were: heterozygote for A1626G and WT for the rest of the alleles 14% of patients, heterozygote for C170T, A1626G, A1056G and WT for the rest 14% of patients, and heterozygote for C170T, A1056G and WT for the rest 10% of patients. All patients were APC WT. The first two groups were significantly younger at diagnosis than the third group.

Conclusions

Specific polymorphisms in the APC and CD24 genes may play a role in pancreatic cancer development. Correlation with survival requires a larger cohort.



Autor: Sivan Shamai, Ilana Nabiochtchikov, Sarah Kraus, Sally Zigdon, Dina Kazanov, Michal Itzhak-Klutch, Carmit Eizner, Nadir Arber , R

Fuente: http://plos.srce.hr/



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