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Mediators of Inflammation - Volume 2007 2007, Article ID 12367, 3 pages

Clinical Study

Department of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan

Division of Japanese Oriental Medicine, Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, Japan

Department of Japanese Oriental Medicine, Kanebo Memorial hospital, Kobe, Hyogo 652-0855, Japan

Department of Japanese Oriental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

Received 14 December 2006; Revised 25 January 2007; Accepted 25 January 2007

Copyright © 2007 Toshiaki Kogure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Anti-cyclic citrullinated peptide CCP antibody is a useful marker for thediagnosis and prognosis of rheumatoid arthritis RA. Recently, clinicalsignificance of follow-up in anti-CCP antibody titer has been pointedout. Thus, we investigated the serial determination in anti-CCP antibodiestiter in RA patients.Six patients with RA, who were followed up for longer than 5 years, wereassessed in anti-CCP antibodies and radiographs Larsen score. Anti-CCPantibodies in frozen sera were measured using ELISA. As a result, 6 patientswith RA were divided into two groups: one possessed high titers withoutvariation, and the other was without high titers. Joint damage progressedduring observation in 2 out of 3 patients with high anti-CCP titers in aretrospective assessment. In contrast, the RA patient, whose anti-CCP titerdecreases although it had been high titer at baseline, did not show increasein the Larsen score. These findings suggest that it might be necessary toanalyze changes in anti-CCP to predict the prognosis of joint destruction.

Autor: Toshiaki Kogure, Takeshi Tatsumi, Hiroshi Fujinaga, Atsushi Niizawa, and Katsutoshi Terasawa



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