Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water InhalationReportar como inadecuado




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The Scientific World JournalVolume 2013 2013, Article ID 927835, 7 pages

Clinical Study

Department of Medical Sciences, Research Centre on Asthma and COPD, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

Department of Life Science and Biotechnology, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy

Received 24 August 2013; Accepted 1 October 2013

Academic Editors: A. De Roux, N. Scichilone, L. A. Stanciu, and F. Varoli

Copyright © 2013 Marco Contoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Inhalation of thermal water with antioxidant properties is empirically used for COPD. Aims. To evaluate the effects of sulphurous thermal water reducing agents on airway oxidant stress and clinical outcomes in COPD. Methods. Forty moderate-to-severe COPD patients were randomly assigned to receive 12-day inhalation with sulphurous thermal water or isotonic saline. Patients were assessed for superoxide anion production in the exhaled breath condensate and clinical outcomes at recruitment, the day after the conclusion of the 12-day inhalation treatment, and one month after the end of the inhalation treatment. Results. Inhalation of reducing agents resulted in a significant reduction of production in exhaled breath condensate of COPD patients at the end of the inhalatory treatment and at followup compared to baseline. A significant improvement in the COPD assessment test CAT questionnaire was shown one month after the end of the inhalatory treatment only in patients receiving sulphurous water. Conclusion. Thermal water inhalation produced an in vivo antioxidant effect and improvement in health status in COPD patients. Larger studies are required in order to evaluate whether inhalation of thermal water is able to modify relevant clinical outcomes of the disease the study was registered at clinicaltrial.gov—identifier: NCT01664767.





Autor: Marco Contoli, Giulia Gnesini, Giacomo Forini, Brunilda Marku, Alessia Pauletti, Anna Padovani, Paolo Casolari, Liliana Tau

Fuente: https://www.hindawi.com/



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