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Mediators of Inflammation - Volume 2014 2014, Article ID 605280, 9 pages -

Clinical Study

Section of Sleep Medicine, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA

Sleep Unit, Instituto Carlos III.CIBERES, Spain

CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain

Hospital Universitario de Burgos HUBU, Burgos, Spain

Hospital Universitario Valdecilla, Santander, Spain

Hospital Val d-Hebron, Barcelona, Spain

Hospital San Pedro de Alcantara, Caceres, Spain

Servicio de Investigación, Hospital Universitario Araba BioAraba, Universidad del País Vasco UPV-EHU, Vitoria, Spain

Received 13 March 2014; Revised 17 April 2014; Accepted 1 May 2014; Published 1 June 2014

Academic Editor: Jean Louis Pepin

Copyright © 2014 Alex Gileles-Hillel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Obesity and obstructive sleep apnea syndrome OSA are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic PSG variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese Spanish children ages 4–15 years were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. Results. 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index RDI of 3 events-hour total sleep time TST. BMI, gender, and age were similar in OSA and no-OSA children. Monocyte chemoattractant protein-1 MCP-1 and plasminogen activator inhibitor-1 PAI-1 levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA i.e., AHI > 5-hrTST; , while MCP-1 levels were associated with more prolonged nocturnal hypercapnia . Conclusion. IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA. This trial is registered with ClinicalTrials.gov NCT01322763.





Autor: Alex Gileles-Hillel, María Luz Alonso-Álvarez, Leila Kheirandish-Gozal, Eduard Peris, José Aurelio Cordero-Guevara, Joaqui

Fuente: https://www.hindawi.com/



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