Enrichment of Minor Alleles of Common SNPs and Improved Risk Prediction for Parkinsons DiseaseReportar como inadecuado




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Parkinson disease PD is the second most common neurodegenerative disorder in the aged population and thought to involve many genetic loci. While a number of individual single nucleotide polymorphisms SNPs have been linked with PD, many remain to be found and no known markers or combinations of them have a useful predictive value for sporadic PD cases. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content MAC in an individual, have recently been shown to be linked with quantitative variations of numerous complex traits in model organisms with higher MAC more likely linked with lower fitness. Here we found that PD cases had higher MAC than matched controls. A set of 37564 SNPs with MA MAF < 0.4 more common in cases P < 0.05 was found to have the best predictive accuracy. A weighted risk score calculated by using this set can predict 2% of PD cases 100% specificity, which is comparable to using familial PD genes to identify familial PD cases. These results suggest a novel genetic component in PD and provide a useful genetic method to identify a small fraction of PD cases.



Autor: Zuobin Zhu, Dejian Yuan, Denghui Luo, Xitong Lu, Shi Huang

Fuente: http://plos.srce.hr/



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