Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In VivoReportar como inadecuado

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Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 5706751, 7 pages -

Research Article

Department of Radiology, The First Hospital of Jiaxing, 1882 Zhonghuan South Road, Jiaxing, Zhejiang 314000, China

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China

Received 21 January 2016; Accepted 25 February 2016

Academic Editor: Ciprian Tomuleasa

Copyright © 2016 Yijuan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have demonstrated that grape seed proanthocyanidins GSPs could effectively scavenge hydroxyl radical in a dose-dependent manner. Since most of the ionizing radiation- IR- induced injuries were caused by , this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks DSBs and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells WBC from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde MDA, thus improving the survival rates of mice after ionizing radiation. It is suggested that GSPs have a potential as an effective and safe radioprotective agent.




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