Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo SurvivalReportar como inadecuado




Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Mediators of Inflammation - Volume 2017 2017, Article ID 8491383, 8 pages - https:-doi.org-10.1155-2017-8491383

Review ArticleDepartment of Medicine, Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Correspondence should be addressed to Gregory M. Gauthier

Received 18 November 2016; Accepted 12 April 2017; Published 23 May 2017

Academic Editor: Anamélia L. Bocca

Copyright © 2017 Gregory M. Gauthier. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae 22–25°C and yeast 37°C. This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence. In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses. This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection.





Autor: Gregory M. Gauthier

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados