Hypocholesterolemic and Hepatoprotective Effects of “Triguero” Asparagus from Andalusia in Rats Fed a High Cholesterol DietReportar como inadecuado




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Evidence-Based Complementary and Alternative MedicineVolume 2012 2012, Article ID 814752, 6 pages

Research Article

Department of Pharmacology, Faculty of Pharmacy, University of Seville, C. Professor García Gonzalez 2, 41012 Seville, Spain

Department of Pharmacology, Therapeutics and Toxicology, Institute of Neurosciences, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

Received 26 May 2011; Accepted 9 September 2011

Academic Editor: Dietlind Wahner-Roedler

Copyright © 2012 M.D. García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cultivated species of the wild autochthonous Asparagus officinalis in Andalusia in Spain is commonly called “triguero” asparagus. This vegetable has traditionally been very much appreciated for its organoleptic and nutritional characteristics. This study has been designed to evaluate the potential effect of different concentrations of freeze-dried asparagus 500, 250, and 125 mg-Kg of body weight-day on oxidative status and lipid profile in rats fed a cholesterol-rich diet. After five weeks of treatment, doses of 250 and 500 mg-Kg of asparagus were able to significantly reduce total cholesterol and LDL cholesterol levels. Atherogenic index was also significantly reduced in a dose-dependent manner by administrating freeze-dried asparagus. A beneficial effect was observed in the HDL cholesterol levels in asparagus-fed groups although the increase was not significant. Consumption of asparagus also improved antioxidant status, assayed superoxide dismutase SOD and catalase CAT enzymes, and protected against lipid peroxidation. These results show that the intake of green asparagus from Andalusia Spain helps to regulate plasma lipid levels and prevents oxidative damage in hypercholesterolemic conditions.





Autor: M.D. García, R. De la Puerta, M. T. Sáenz, A. Marquez-Martín, and M. A. Fernández-Arche

Fuente: https://www.hindawi.com/



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