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ADMET and DMPK, Vol.3 No.2 July 2015. -

The purpose of this study was to prepare polymeric microspheres containing Ketoprofen KFN by single emulsion oil-in-water o-w solvent evaporation method. Polycaprolactone PCL, biocompatible polymer, was used for the preparation of sustained released microspheres of KFN. A Plackett–Burman design was employed by using the Design-Expert® software Version- 9.0.3.1, Stat-Ease Inc., Minneapolis, MN. Eleven factors out of six processing factors were investigated in order to enhance the encapsulation efficiency EE of the microspheres. The resultant microspheres were characterized for their size, morphology, EE, and drug release. Imaging of particles was performed by field emission scanning electron microscopy. Interaction between the drug and polymers were investigated by Fourier transform infrared FTIR spectroscopy, X-ray powder diffractometry XRPD and Differential Scanning Calorimetry DSC. Graphical and mathematical analyses of the design showed that concentration of factor PCL B and varying speed F, revolution per minute, rpm were significant negative effect on the EE and identified as the significant factor determining the EE of the microspheres. The microspheres showed high % EE 31.18 % to 96.81 %. The microspheres were found to be discrete, oval with porous surface. The FTIR analysis confirmed no interaction of KFN with the polymer. The XRPD revealed the dispersion of drug within microspheres formulation. Sustained drug release profile over 12 h was achieved by PCL polymer. In conclusion, polymeric microspheres containing KFN can be successfully prepared using the technique of experimental design, and these results helped in finding the optimum formulation variables for EE of microspheres.

Plackett–Burman design; encapsulation efficiency; sustained release



Autor: Pankaj Wagh - ; Department of Pharmaceutical Technology , University Institute of Chemical Technology, North Maharashtra Universi

Fuente: http://hrcak.srce.hr/



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