Fast-resorbable antibiotic-loaded hydrogel coating to reduce post-surgical infection after internal osteosynthesis: a multicenter randomized controlled trial Reportar como inadecuado




Fast-resorbable antibiotic-loaded hydrogel coating to reduce post-surgical infection after internal osteosynthesis: a multicenter randomized controlled trial - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Orthopaedics and Traumatology

, Volume 18, Issue 2, pp 159–169

First Online: 02 February 2017Received: 19 July 2016Accepted: 31 December 2016DOI: 10.1007-s10195-017-0442-2

Cite this article as: Malizos, K., Blauth, M., Danita, A. et al. J Orthop Traumatol 2017 18: 159. doi:10.1007-s10195-017-0442-2

Abstract

BackgroundInfection is one of the main reasons for failure of orthopedic implants. Antibacterial coatings may prevent bacterial adhesion and biofilm formation, according to various preclinical studies. The aim of the present study is to report the first clinical trial on an antibiotic-loaded fast-resorbable hydrogel coating Defensive Antibacterial Coating, DAC to prevent surgical site infection, in patients undergoing internal osteosynthesis for closed fractures.

Materials and methodsIn this multicenter randomized controlled prospective study, a total of 256 patients in five European orthopedic centers who were scheduled to receive osteosynthesis for a closed fracture, were randomly assigned to receive antibiotic-loaded DAC or to a control group without coating. Pre- and postoperative assessment of laboratory tests, wound healing, clinical scores and X-rays were performed at fixed time intervals.

ResultsOverall, 253 patients were available with a mean follow-up of 18.1 ± 4.5 months range 12–30. On average, wound healing, clinical scores, laboratory tests and radiographic findings did not show any significant difference between the two groups. Six surgical site infections 4.6% were observed in the control group compared to none in the treated group P < 0.03. No local or systemic side-effects related to the DAC hydrogel product were observed and no detectable interference with bone healing was noted.

ConclusionsThe use of a fast-resorbable antibiotic-loaded hydrogel implant coating provides a reduced rate of post-surgical site infections after internal osteosynthesis for closed fractures, without any detectable adverse event or side-effects.

Level of evidence2.

KeywordsInfection Prevention Osteosynthesis DAC Hydrogel Coating 



Autor: Kostantinos Malizos - Michael Blauth - Adrian Danita - Nicola Capuano - Riccardo Mezzoprete - Nicola Logoluso - Lorenzo Dra

Fuente: https://link.springer.com/







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