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Stroke Research and TreatmentVolume 2012 2012, Article ID 362941, 5 pages

Review ArticleDepartment of Neurology, General Hospital Zabok, Zabok, Croatia

Received 8 October 2011; Accepted 21 January 2012

Academic Editor: Arijana Lovrencic-Huzjan

Copyright © 2012 Sanja Kovacic and Mirjana Bakran. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.

Autor: Sanja Kovacic and Mirjana Bakran



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