Increased plasma levels of glucose-dependent insulinotropic polypeptide are associated with decreased postprandial energy expenditure after modern Japanese mealsReportar como inadecuado




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European Journal of Nutrition

, Volume 56, Issue 4, pp 1693–1705

First Online: 25 April 2016Received: 25 December 2014Accepted: 15 April 2016DOI: 10.1007-s00394-016-1216-y

Cite this article as: Osaki, N., Suzukamo, C., Onizawa, K. et al. Eur J Nutr 2017 56: 1693. doi:10.1007-s00394-016-1216-y

Abstract

PurposeThe nutritional changes that have accompanied the modernization of Japanese dietary patterns have led to significant increases in the number of people who are overweight or obese. This study aimed to clarify the effects of these nutritional changes on postprandial energy expenditure and the release of metabolism-regulating hormones.

MethodsThe total daily energy content 20 % breakfast, 40 % lunch, and 40 % dinner and macronutrient composition carbohydrate-fat-protein was 8807.3 kJ and 364.3:30.1:66.4 g for the traditional test diet and 9217.6 kJ and 331.7:66.1:76.9 g for the modern test diet. In experiment 1, nine healthy Japanese men participated in a crossover study during which they ingested a test diet comprising three meals; postprandial blood parameters were measured after each meal. In experiment 2, another ten men participated in a crossover study during which they ingested 2 meals, after which metabolic responses and blood variables were evaluated.

ResultsThe modern diet induced greater blood levels of glucose-dependent insulinotropic polypeptide GIP and ghrelin than did the traditional diet. The expected increase in postprandial energy expenditure ∆REE tended to be dampened after the modern compared with the traditional diet. GIP was inversely correlated with ∆REE after lunch, and ghrelin was positively associated with ∆REE.

ConclusionBoth GIP and ghrelin are robust indicators of postprandial energy expenditure. The nutritional changes accompanying the modernization of Japanese dietary patterns may increase the levels of the anabolic intestinal hormone GIP, which is associated with ∆REE, in the Japanese population. The contribution of an increased ghrelin concentration to the decreased ∆REE after the modern diet warrants further investigation.

KeywordsGastrointestinal hormones Ghrelin Glucose-dependent insulinotropic polypeptide Japanese meal Postprandial energy expenditure AbbreviationsCCKCholecystokinin

GIPGlucose-dependent insulinotropic polypeptide

GLP-1Glucagon-like peptide-1

iAUCIncremental area under the curve

NEFANon-esterified fatty acid

PPPancreatic polypeptide

PYYPeptide YY

REEResting energy expenditure

TGTriglycerides

VCO2Carbon dioxide consumption

VO2Oxygen consumption





Autor: Noriko Osaki - Chika Suzukamo - Kouji Onizawa - Tadashi Hase - Akira Shimotoyodome

Fuente: https://link.springer.com/



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