11C-Acetate PET Imaging in Patients with Multiple SclerosisReportar como inadecuado




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Background

Activation of glial cells is a cardinal feature in multiple sclerosis MS pathology, and acetate has been reported to be selectively uptaken by astrocytes in the CNS. The aim of this study was to investigate the efficacy of PET with 11C-acetate for MS diagnosis.

Materials and Methods

Six patients with relapsing-remitting MS and 6 healthy volunteers HV were enrolled. The 11C-acetate brain uptake on PET was measured in patients with MS and HV. Volume-of-interest analysis of cerebral gray and white matter based on the segmentation technique for co-registered MRI and voxel-based statistical parametric analysis were performed. Correlation between 11C-acetate uptake and the lesion number in T1- and T2- weighted MR images were also assessed.

Results

The standardized uptake value SUV of 11C-acetate was increased in both white and gray matter in MS patients compared to HV. Voxel-based statistical analysis revealed a significantly increased SUV relative to that in the bilateral thalami SUVt in a broad area of white matter, particularly in the subcortical white matter of MS patients. The numbers of T2 lesions and T1 black holes were significantly correlated with SUV of 11C-acetate in white and gray matter.

Conclusions

The 11C-acetate uptake significantly increased in MS patients and correlated to the number of MRI lesions. These preliminary data suggest that 11C-acetate PET can be a useful clinical examination for MS patients.



Autor: Kazushiro Takata , Hiroki Kato , Eku Shimosegawa, Tatsusada Okuno, Toru Koda, Tomoyuki Sugimoto, Hideki Mochizuki, Jun Hatazawa ,

Fuente: http://plos.srce.hr/



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