Construction and evaluation of a quantitative arterial spin labeling brain perfusion template at 3TReportar como inadecuado

Construction and evaluation of a quantitative arterial spin labeling brain perfusion template at 3T - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 VisAGeS - Vision, Action et Gestion d-informations en Santé IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE, INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique 2 Service de radiologie et imagerie médicale Rennes 3 Plateforme neurinfo Rennes

Abstract : Arterial spin labeling ASL allows non-invasive imaging and quantification of brain perfusion by magnetically labeling blood in the brain-feeding arteries. ASL has been used to study cerebrovascular diseases, brain tumors and neurodegenerative disorders as well as for functional imaging. The use of a perfusion template could be of great interest to study inter-subject regional variation of perfusion and to perform automatic detection of individual perfusion abnormalities. However, low spatial resolution and partial volume effects PVE issues inherent to ASL acquisitions remain to be solved. The purpose of this study is to enhance the template quality by using DARTEL non-rigid registration and by correcting for PVE. PICORE-Q2TIPS ASL datasets were acquired on 25 healthy volunteers at 3T. Four methods of creating the template were evaluated using leave-one-out cross correlation. Subsequently, these methods were applied to hyper-perfusion detection on functional ASL data of 8 healthy volunteers and compared with the standard generalized linear model GLM activation detection.

keyword : atlases arterial spin labeling partial volume functional MRI MRI

Autor: Jan Petr - Jean-Christophe Ferré - Elise Bannier - Hélène Raoult - Jean-Yves Gauvrit - Christian Barillot -



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