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BioMed Research International - Volume 2015 2015, Article ID 319745, 8 pages -

Review Article

Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain

Infection, Immunity and Digestive Pathology Group, Research Institute Marqués de Valdecilla IDIVAL, 39008 Santander, Spain

Transplant and Autoimmunity Group, Research Institute Marqués de Valdecilla IDIVAL, 39008 Santander, Spain

Immunology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain

Received 24 April 2015; Revised 26 August 2015; Accepted 30 August 2015

Academic Editor: Luca Miele

Copyright © 2015 María Teresa Arias-Loste et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonalcoholic fatty liver disease NAFLD has become a major health issue in western countries in parallel with the dramatic increase in the prevalence of obesity and all obesity related conditions, including respiratory diseases as obstructive sleep apnea-hypopnea syndrome OSAHS. Interestingly, the severity of the liver damage in obesity-related NAFLD has been associated with the concomitant presence of OSAHS. In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis, may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NFκB. Thus, the severity of liver involvement in obese NAFLD patients with a concomitant diagnosis of OSAHS could be explained. In this review, we focus on the molecular mechanisms underlying the hepatic response to chronic intermittent hypoxia and its interaction with innate immunity in obesity-related NAFLD.





Autor: María Teresa Arias-Loste, Emilio Fábrega, Marcos López-Hoyos, and Javier Crespo

Fuente: https://www.hindawi.com/



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