Hyperinsulinemia: a Cause of ObesityReport as inadecuate

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Current Obesity Reports

, Volume 6, Issue 2, pp 178–186

Topical Collection on Obesity Treatment


Purpose of ReviewThis perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance IR. We highlight the need to investigate potential environmental obesogens and toxins.

Recent FindingsThe prequel to severe metabolic disease includes three interacting components that are abnormal: a IR, b elevated lipids and c elevated basal insulin HI. HI is more common than IR and is a significant independent predictor of diabetes.

SummaryWe hypothesize that 1 the initiating defect is HI that increases nutrient consumption and hyperlipidemia HL; 2 the cause of HI may include food additives, environmental obesogens or toxins that have entered our food supply since 1980; and 3 HI is sustained by HL derived from increased adipose mass and leads to IR. We suggest that HI and HL are early indicators of metabolic dysfunction and treating and reversing these abnormalities may prevent the development of more serious metabolic disease.

KeywordsHyperinsulinemia Insulin resistance Hyperlipidemia Energy efficiency ROS Redox AbbreviationsHIHyperinsulinemia


IRInsulin resistance

PI3KPhosphoinositide 3-kinase

VMHVentromedial hypothalamus


This article is part of the Topical Collection on Obesity Treatment

Author: Karel A. Erion - Barbara E. Corkey

Source: https://link.springer.com/

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