Characterization of CD30-CD30L Cells in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid ArthritisReportar como inadecuado

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Journal of Immunology Research - Volume 2015 2015, Article ID 729654, 10 pages -

Research Article

Department of Medicine, University of Verona, 37134 Verona, Italy

Institute G. Gaslini, 16147 Genova, Italy

University of Genova, 16132 Genova, Italy

Received 19 September 2014; Accepted 6 January 2015

Academic Editor: Ethan M. Shevach

Copyright © 2015 Alessandro Barbieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The CD30-CD30L signalling system has been implicated in the pathogenesis of several autoimmune and inflammatory conditions. In rheumatoid arthritis RA, soluble CD30 sCD30 levels reflect the recruitment of CD30

T cells into the inflamed joints and correlate with a positive response to immunosuppressive therapy. The aim of our report was to clarify the role of CD30-CD30L signalling system in the pathogenesis of RA. Our analysis of the CD30L

T cell subsets in peripheral blood PB and synovial fluid SF of RA patients and of the related cytokine profiles suggests the involvement of CD30-CD30L signalling in polarization of T cells towards a Th17 phenotype with proinflammatory features. Moreover, in RA SF nearly 50% of Treg cells express CD30, probably as an attempt to downmodulate the ongoing inflammation. We also show here that the engagement of CD30L on neutrophils stimulated with CD30-Fc chimera may play a crucial role in RA inflammation since activated neutrophils release IL-8, thus potentially amplifying the local inflammatory damage. In conclusion, the results obtained suggest that the complex CD30-CD30L signalling pathway is implicated in the pathogenesis and progression of RA synovitis through a concerted action on several immune effector cells.

Autor: Alessandro Barbieri, Marzia Dolcino, Elisa Tinazzi, Antonella Rigo, Giuseppe Argentino, Giuseppe Patuzzo, Andrea Ottria, Ru



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