Protective Role of Plant Sterol and Stanol Esters in Liver Inflammation: Insights from Mice and HumansReportar como inadecuado




Protective Role of Plant Sterol and Stanol Esters in Liver Inflammation: Insights from Mice and Humans - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The inflammatory component of non–alcoholic steatohepatitis NASH can lead to irreversible liver damage. Therefore there is an urgent need to identify novel interventions to combat hepatic inflammation. In mice, omitting cholesterol from the diet reduced hepatic inflammation. Considering the effects of plant sterol-stanol esters on cholesterol metabolism, we hypothesized that plant sterol-stanol esters reduces hepatic inflammation. Indeed, adding plant sterol-stanol esters to a high-fat-diet reduced hepatic inflammation as indicated by immunohistochemical stainings and gene expression for inflammatory markers. Finally, adding sterol-stanol esters lowered hepatic concentrations of cholesterol precursors lathosterol and desmosterol in mice, which were highly elevated in the HFD group similarly as observed in severely obese patients with NASH. In vitro, in isolated LPS stimulated bone marrow derived macrophages desmosterol activated cholesterol efflux whereas sitostanol reduced inflammation. This highly interesting observation that plant sterol-stanol ester consumption leads to complete inhibition of HFD-induced liver inflammation opens new venues in the treatment and prevention of hepatic inflammation.



Autor: Jogchum Plat , Tim Hendrikx, Veerle Bieghs, Mike L. J. Jeurissen, Sofie M. A. Walenbergh, Patrick J. van Gorp, Els De Smet, Mauri

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados