Running a Marathon Induces Changes in Adipokine Levels and in Markers of Cartilage Degradation – Novel Role for ResistinReport as inadecuate

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Running a marathon causes strenuous joint loading and increased energy expenditure. Adipokines regulate energy metabolism, but recent studies have indicated that they also exert a role in cartilage degradation in arthritis. Our aim was to investigate the effects of running a marathon on the levels of adipokines and indices of cartilage metabolism. Blood samples were obtained from 46 male marathoners before and after a marathon run. We measured levels of matrix metalloproteinase-3 MMP-3, cartilage oligomeric protein COMP and chitinase 3-like protein 1 YKL-40 as biomarkers of cartilage turnover and-or damage and plasma concentrations of adipokines adiponectin, leptin and resistin. Mean marathon time was 3∶30∶46±0∶02∶46 h:min:sec. The exertion more than doubled MMP-3 levels and this change correlated negatively with the marathon time r = –0.448, p = 0.002. YKL-40 levels increased by 56% and the effect on COMP release was variable. Running a marathon increased the levels of resistin and adiponectin, while leptin levels remained unchanged. The marathon-induced changes in resistin levels were positively associated with the changes in MMP-3 r = 0.382, p = 0.009 and YKL-40 r = 0.588, p<0.001 and the pre-marathon resistin levels correlated positively with the marathon induced change in YKL-40 r = 0.386, p = 0.008. The present results show the impact of running a marathon, and possible load frequency, on cartilage metabolism: the faster the marathon was run, the greater was the increase in MMP-3 levels. Further, the results introduce pro-inflammatory adipocytokine resistin as a novel factor, which enhances during marathon race and associates with markers of cartilage degradation.

Author: Katriina Vuolteenaho, Tiina Leppänen, Riina Kekkonen, Riitta Korpela, Eeva Moilanen



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