Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood FlowReport as inadecuate




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Radiology Research and PracticeVolume 2013 2013, Article ID 694803, 5 pages

Clinical Study

Wolfson Molecular Imaging Centre, Cancer and Enabling Sciences, University of Manchester, 23 Palatine Road, Withington, Manchester M20 3LJ, UK

Biomedical Imaging Institute, University of Manchester, Manchester M20 9PL, UK

Department of Anaesthetics, Salford Royal Hospital, Stott Lane, Salford, Greater Manchester M6 8HD, UK

Acute Intensive Care Unit, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK

Received 28 August 2013; Revised 8 November 2013; Accepted 13 November 2013

Academic Editor: Hans-Joachim Mentzel

Copyright © 2013 John R. Cain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To compare a semiopen breathing circuit with a non-rebreathing Hudson mask for MRI experiments involving gas delivery. Methods and Materials. Cerebral blood flow CBF was measured by quantitative phase contrast angiography of the internal carotid and basilar arteries in 18 volunteers 20–31 years. In 8 subjects, gases were delivered via a standard non-rebreathing Hudson mask. In 10 subjects, gases were delivered using a modified “Mapleson A” semiopen anesthetic gas circuit and mouthpiece. All subjects were given 100% O2, medical air, and carbogen gas 95% O2 and 5% CO2 delivered at 15 L-min in a random order. Results. The Hudson mask group showed significant increases in CBF in response to increased FiCO2 compared to air +9.8%. A small nonsignificant reduction in CBF −2.4% was seen in response to increased inspired concentrations of oxygen FiO2. The Mapleson A group showed significantly larger changes in CBF in response to both increased inspired concentrations of carbon dioxide FiCO2 +32.2%, and FiO2 −14.6%, . Conclusions. The use of an anaesthetic gas delivery circuit avoids entrainment of room air and rebreathing effects that may otherwise adversely affect the experimental results.





Author: John R. Cain, Laura M. Parkes, Peter Eadsforth, Susan C. Beards, and Alan Jackson

Source: https://www.hindawi.com/



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