Associations between serum 25OHD concentrations and prevalent asthma among children living in communities with differing levels of urbanization: a cross-sectional studyReportar como inadecuado

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Asthma Research and Practice

, 3:5

First Online: 02 June 2017Received: 20 December 2016Accepted: 23 May 2017DOI: 10.1186-s40733-017-0033-2

Cite this article as: Pollard, S.L., Lima, J.J., Romero, K. et al. asthma res and pract 2017 3: 5. doi:10.1186-s40733-017-0033-2


BackgroundPrior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children.

MethodsIn this cross-sectional analysis nested in a case-control study, we analyzed serum 25OHD concentrations in 413 children with asthma and 471 children without asthma living in two geographically adjacent study communities Pampas and Villa El Salvador. We measured total and antigen-specific IgE levels, pulmonary function, asthma control, and exhaled nitric oxide.

ResultsMean 25OHD concentrations were 25.2 ng-mL SD 10.1 in children with asthma and 26.1 ng-mL SD 13.7 in children without asthma p = 0.28. Vitamin D deficiency 25OHD < 20 ng-ml was more common in Pampas than in Villa El Salvador 52.7% vs. 10.5%; p < 0.001. In the overall study population, a 10 ng-ml decrease in serum 25OHD concentrations was not significantly associated with odds of asthma OR 1.09, 95% CI: 0.94 to 1.25. However, vitamin D deficiency was associated with a 1.6-fold increase in odds of asthma in the overall cohort 95% CI: 1.14 to 2.25. After stratifying by site, a 10 ng-mL decrease in serum 25OHD concentrations was associated with 18% higher odds of having asthma in Pampas OR = 1.18, 95% CI 1.02 to 1.38, whereas there was no significant association between 25OHD concentrations and asthma in Villa El Salvador OR = 0.95, 95% CI 0.87 to 1.05. Combined data from these geographically adjacent populations suggests a possible threshold for the relationship between 25OHD levels and asthma at approximately 27.5 ng-ml. Serum 25OHD concentrations were not clearly associated with asthma control, total serum IgE, atopy, or airway inflammation.

ConclusionSerum 25OHD concentrations were inversely associated with asthma in one study community with a high prevalence of deficiency. Studies are needed to investigate a possible threshold 25OHD concentration after which higher vitamin D levels show no further benefit for asthma.

KeywordsAsthma Pediatric asthma Vitamin D 25OHD Nutrition Urbanization AbbreviationsACTAsthma Control Test

BMIBody Mass Index

FeNOFractional exhaled nitric oxide

FEV1Forced expiratory volume in 1 second

FVCForced vital capacity

IgEImmunoglobulin E

SESSocioeconomic status

Electronic supplementary materialThe online version of this article doi:10.1186-s40733-017-0033-2 contains supplementary material, which is available to authorized users.

Autor: Suzanne L. Pollard - John J. Lima - Karina Romero - Carla Tarazona-Meza - Edward Mougey - Katherine Tomaino - Gary Malpar


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