Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adultsReportar como inadecuado




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BMC Ophthalmology

, 17:83

Retina

Abstract

BackgroundThis cross sectional investigation included 12,966 subjects with hypertension, a cohort of the China Stroke Primary Prevention Trial CSPPT, a randomized, multicenter clinical trial. This study aimed to explore the correlation between serum uric acid SUA concentration and hypertensive retinopathy in hypertensive adults.

MethodsDiagnosis of hypertensive retinopathy was determined by non-mydriatic fundus photography and classified with Keith-Wagener-Barker KWB system. The correlation of SUA levels with hypertensive retinopathy prevalence and severity was assessed by statistical analysis.

Results9848 75.95% subjects were diagnosed with hypertensive retinopathy with the following retinopathy grade distribution: grade 1: 58.80%, grade 2: 14.81%, and grade 3–4: 2.34%. SUA levels were significantly associated with hypertensive retinopathy prevalence. Patients with hypertensive retinopathy had higher SUA levels than those without hypertensive retinopathy. Patients in the highest uric acid quartile had an odds ratio for hypertensive retinopathy of 1.21 compared to patients in the lowest uric acid quartile OR = 1.21, 95% CI: 1.05–1.40, P = 0.008. When compared to the non-hyperuricemia group, those in the hyperuricemia group had an odds ratio for hypertensive retinopathy of 1.18OR = 1.18, 95% CI: 1.05–1.33, P = 0.004. Every 1 mg-dl increase in uric acid concentration was significantly associated with a 6% higher odds of hypertensive retinopathy OR = 1.06, 95% CI: 1.02–1.10, P = 0.002.

ConclusionsThe prevalence of hypertensive retinopathy was high 75.95% among hypertensives in our patients cohort. In addition, SUA concentration was significantly associated with hypertensive retinopathy.

KeywordsSerum Uric Acid Concentration Hypertensive Retinopathy Hypertension Hyperuricemia Keith-Wagener-Barker system 



Autor: Xuling Chen - Ying Meng - Jun Li - Hiacheng She - Liang Zhao - Jing Zhang - Yuan Peng - Kun Shang - Yadi Zhang - Xiaopeng

Fuente: https://link.springer.com/







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