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BMC Medicine

, 15:109

Spotlight on landmark oncology trials


For metastatic soft tissue sarcoma STS patients not eligible for surgery, systemic treatments, including standard chemotherapy and newer biological compounds, still play the most relevant role in the management of the disease. An anthracycline and alkylating agent combination has formed the cornerstone of chemotherapy in STS for more than 30 years, with its value over that of administration of anthracycline as a single agent still being debated. Efforts have been made to improve the activity and minimise the toxicity of the combination, as well as to explore the upfront efficacy of agents known to be active in sarcoma and to develop new biological compounds. Nevertheless, beyond the first line, evidence for medical treatment in STS is less robust and all the more driven by histology. Thus, the introduction of kinases and small molecule inhibitors in the treatment armamentarium for STS is a major achievement in this setting. Preliminary data on immunotherapy are also available and discussed in this review.

KeywordsSarcoma Advanced sarcoma Metastatic sarcoma Chemotherapy Tyrosine kinase inhibitors VEGF inhibitors Immunotherapy Survival 

Autor: Anna Maria Frezza - Silvia Stacchiotti - Alessandro Gronchi


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