Prediction of Glycated Hemoglobin Levels at 3 Months after Metabolic Surgery Based on the 7-Day Plasma Metabolic ProfileReportar como inadecuado




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Metabolic surgery has been shown to provide better glycemic control for type 2 diabetes than conventional therapies. Still, the outcomes of the surgery are variable, and prognostic markers reflecting the metabolic changes by the surgery are yet to be established. NMR-based plasma metabolomics followed by multivariate regression was used to test the correlation between the metabolomic profile at 7-days after surgery and glycated hemoglobin HbA1c levels at 3-months and up to 12 months with less patients, and to identify the relevant markers. Metabolomic profiles at 7-days could differentiate the patients according to the HbA1c improvement status at 3-months. The HbA1c values were predicted based on the metabolomics profile with partial least square regression, and found to be correlated with the observed values. Metabolite analysis suggested that 3-Hydroxybutyrate 3-HB and glucose contributes to this prediction, and the 3-HB-glucose exhibited a modest to good correlation with the HbA1c level at 3-months. The prediction of 3-month HbA1c using 7-day metabolomic profile and the suggested new criterion 3-HB-glucose could augment current prognostic modalities and help clinicians decide if drug therapy is necessary.



Autor: Hyuk Nam Kwon , Yeon Ji Lee , Ju-Hee Kang , Ji-ho Choi, Yong Jin An, Sunmi Kang, Dae Hyun Lee, Young Ju Suh, Yoonseok Heo , Sungh

Fuente: http://plos.srce.hr/



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