Relationship between Lifestyle and Health Factors and Severe Lower Urinary Tract Symptoms LUTS in 106,435 Middle-Aged and Older Australian Men: Population-Based StudyReportar como inadecuado




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Background

Despite growing interest in prevention of lower urinary tract symptoms LUTS through better understanding of modifiable risk factors, large-scale population-based evidence is limited.

Objective

To describe risk factors associated with severe LUTS in the 45 and Up Study, a large cohort study.

Design, Setting, and Participants

A cross-sectional analysis of questionnaire data from 106,435 men aged ≥45 years, living in New South Wales, Australia.

Outcome Measures and Statistical Analysis

LUTS were measured by a modified version of the International Prostate Symptom Score m-IPSS. The strength of association between severe LUTS and socio-demographic, lifestyle and health-related factors was estimated, using logistic regression to calculate odds ratios, adjusted for a range of confounding factors.

Results

Overall, 18.3% reported moderate, and 3.6% severe, LUTS. Severe LUTS were more common among men reporting previous prostate cancer 7.6%, total prostatectomy 4.9% or having part of the prostate removed 8.2%. After excluding men with prostate cancer or prostate surgery, the prevalence of moderate-severe LUTS in the cohort n = 95,089 ranged from 10.6% to 35.4% for ages 45–49 to ≥80; the age-related increase was steeper for storage than voiding symptoms. The adjusted odds of severe LUTS decreased with increasing education tertiary qualification versus no school certificate, odds ratio OR = 0.78 0.68–0.89 and increasing physical activity high versus low, OR = 0.83 0.76–0.91. Odds were elevated among current smokers versus never-smokers OR = 1.64 1.43–1.88, obese versus healthy-weight men OR = 1.27 1.14–1.41 and for comorbid conditions e.g., heart disease versus no heart disease, OR = 1.36 1.24–1.49, and particularly for severe versus no physical functional limitation OR = 5.17 4.51–5.93.

Conclusions

LUTS was associated with a number of factors, including modifiable risk factors, suggesting potential targets for prevention.



Autor: David P. Smith , Marianne F. Weber, Kay Soga, Rosemary J. Korda, Gabriella Tikellis, Manish I. Patel, Mark S. Clements, Terry Dwy

Fuente: http://plos.srce.hr/



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