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Parkinson’s Disease - Volume 2015 2015, Article ID 523041, 5 pages -

Research Article

State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, Brazil

Hospital de Clínicas, Federal University of Paraná, Rua General Carneiro 181, 80060-900 Curitiba, PR, Brazil

Received 28 March 2015; Revised 4 June 2015; Accepted 7 June 2015

Academic Editor: Antonio Pisani

Copyright © 2015 Carlos Henrique Ferreira Camargo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Orthostatic hypotension OH is an important nonmotor manifestation of Parkinson’s disease PD. Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler. Objective. To identify possible changes in cerebrovascular reactivity in patients with OH. Methods. Twenty-two individuals were selected and divided into three groups: with and without OH and controls. Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index. Results. PD patients had lower values of basal velocity , postapnea velocity , percentage increase in velocity , and breath-holding index than the controls. Patients with OH had higher values of basal velocity and postapnea velocity but lower values of percentage increase in velocity and breath-holding index than patients without OH. Conclusions. PD patients present with abnormalities in a compensatory mechanism that regulates cerebral blood flow. OH could be an indicator of these abnormalities.





Autor: Carlos Henrique Ferreira Camargo, Eduardo Antunes Martins, Marcos Christiano Lange, Henrique Alvaro Hoffmann, Jissa Jeanete Lu

Fuente: https://www.hindawi.com/



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