Immune Cells in Cancer Therapy and Drug DeliveryReport as inadecuate

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Mediators of Inflammation - Volume 2016 2016, Article ID 5230219, 13 pages -

Review Article

Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland

Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1a, 02-089 Warsaw, Poland

Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland

Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

Received 26 December 2015; Revised 23 February 2016; Accepted 24 March 2016

Academic Editor: Munitta Muthana

Copyright © 2016 Ceren Eyileten et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent studies indicate the critical role of tumour associated macrophages, tumour associated neutrophils, dendritic cells, T lymphocytes, and natural killer cells in tumourigenesis. These cells can have a significant impact on the tumour microenvironment via their production of cytokines and chemokines. Additionally, products secreted from all these cells have defined specific roles in regulating tumour cell proliferation, angiogenesis, and metastasis. They act in a protumour capacity in vivo as evidenced by the recent studies indicating that macrophages, T cells, and neutrophils may be manipulated to exhibit cytotoxic activity against tumours. Therefore therapy targeting these cells may be promising, or they may constitute drug or anticancer particles delivery systems to the tumours. Herein, we discussed all these possibilities that may be used in cancer treatment.

Author: Ceren Eyileten, Kinga Majchrzak, Zofia Pilch, Katarzyna Tonecka, Joanna Mucha, Bartlomiej Taciak, Katarzyna Ulewicz, Katarz



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