Rest tremor revisited: Parkinson’s disease and other disordersReport as inadecuate

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Translational Neurodegeneration

, 6:16

First Online: 16 June 2017Received: 13 March 2017Accepted: 06 June 2017DOI: 10.1186-s40035-017-0086-4

Cite this article as: Chen, W., Hopfner, F., Becktepe, J.S. et al. Transl Neurodegener 2017 6: 16. doi:10.1186-s40035-017-0086-4


Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson’s disease PD, essential tremor and dystonia, have been carried out. Monosymptomatic rest tremor has been further separated from tremor-dominated PD. Rest tremor is also found in dystonic tremor, essential tremor with a rest component, Holmes tremor and a few even rarer conditions. Dopamine transporter imaging and several electrophysiological methods provide additional clues for tremor differential diagnosis. New evidence from neuroimaging and electrophysiological studies has broadened our knowledge on the pathophysiology of Parkinsonian and non-Parkinsonian tremor. Large cohort studies are warranted in future to explore the nature course and biological basis of tremor in common tremor related disorders.

KeywordsTremor Parkinson’s disease Essential tremor Dystonia Pathophysiology AbbreviationsANO3Anoctamin 3 gene

BRrcBrainstem interneuronal inhibition

BTPBenign tremulous Parkinsonism

CETCoherence entrainment test

DATDopamine transporter

DBSDeep brain stimulation

DTDystonic tremor

DYT24Dystonia locus dystonia-24


ETEssential tremor

GNALGuanine nucleotide-binding protein

ITIntention tremor

LIDLevodopa induced dyskinesia

MDSMovement disorder society

mRTMonosymptomatic rest tremor

PDParkinson’s disease

PTPsychogenic tremor

SWEDDsScans without evidence of dopaminergic deficits

TAWDTremor associated with dystonia

TDMTTemporal discrimination movement threshold

TDTTemporal discrimination threshold

VimVentral intermediate nucleus

Author: Wei Chen - Franziska Hopfner - Jos Steffen Becktepe - Günther Deuschl


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