Spectrofluorimetric Method for the Estimation of Erlotinib Hydrochloride in Pure and Pharmaceutical FormulationsReportar como inadecuado




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E-Journal of Chemistry - Volume 8 2011, S1, Pages S304-S308



M.I.C College of Technology, Vijayawada-521180, India

K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada-520 010, India

Received 1 October 2010; Accepted 27 November 2010

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple and sensitive spectrofluorimetric method has been developed for the estimation of erlotinib hydrochloride in pure and pharmaceutical dosage forms. Erlotinib hydrochloride exhibits maximum fluorescence intensity in methanol and the Beer's law was obeyed in the range of 1-5 µg-mL at an excitation wavelength λex of 295 nm and an emission wavelength λem of 339 nm. Stability studies with respect to time and temperature were also carried out. The results obtained were in good agreement with the labelled amounts of the marketed formulations. This method has been statistically evaluated and found to be accurate and precise.





Autor: V. Rajesh, V. Jagathi, K. Sindhuri, and G. Devala Rao

Fuente: https://www.hindawi.com/



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