Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared MiceReportar como inadecuado

Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Neural PlasticityVolume 2012 2012, Article ID 426437, 8 pages

Research Article

Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USA

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA

Received 12 September 2011; Accepted 4 October 2011

Academic Editor: Arianna Maffei

Copyright © 2012 Thomas E. Krahe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The cAMP-response element-binding protein CREB plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing DR. Recent findings indicate that the dorsal lateral geniculate nucleus dLGN of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening delayed DR, DDR and not after chronic DR CDR from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.

Autor: Thomas E. Krahe, Tania A. Seabrook, Ching-Kang J. Chen, Michael A. Fox, and William Guido



Documentos relacionados