Management of Primary Sclerosing Cholangitis: Conventions and ControversiesReport as inadecuate

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Canadian Journal of Gastroenterology - Volume 26 2012, Issue 5, Pages 261-268


Division of Gastroenterology, Western University, London, Canada

Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Centre for Liver Research, University of Birmingham, Birmingham, UK

Received 9 March 2011; Accepted 29 July 2011

Copyright © 2012 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


Primary sclerosing cholangitis PSC is a chronic inflammatory cholangiopathy that results in fibrotic strictures and dilations of the intra- and extrahepatic bile ducts. PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. Using the best available evidence, the present review summarizes the current understanding of the diagnosis, pathogenesis and management of PSC. Despite its rarity, there is an urgent need for collaborative research efforts to advance therapeutic options for PSC beyond liver transplantation.

Author: Natasha Chandok and Gideon M Hirschfield



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