Lifor Solution: An Alternative Preservation Solution in Small Bowel TransplantationReport as inadecuate

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Gastroenterology Research and Practice - Volume 2016 2016, Article ID 3925751, 6 pages -

Research Article

Department of Laparoscopic Surgery Center, Linyi People’s Hospital, Shandong University, Linyi 276000, China

Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China

Received 25 June 2015; Revised 4 August 2015; Accepted 11 August 2015

Academic Editor: Jean-Francois Beaulieu

Copyright © 2016 Mingxiao Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objectives. The intestinal mucosa is extremely sensitive to ischemia. Better intestinal preservation is the first step to improve the results of intestinal transplantation. The aim of the study is to investigate the effect of cold Lifor solution on preservation of swine small bowel. Methods. Swine ileum segments 200 cm were allotransplanted heterotopically after 9-hour cold storage with UW solution group 1, , with Lifor solution group 2, , or without storage group 3, , respectively. After cold storage, mucosal adenosine triphosphate ATP concentrations and histopathologic analysis after preservation were performed. At day 7 after the transplantation, intestinal absorptive function was also observed. Results. After 9 h cold preservation, pathological changes, the content of ATP in the intestinal mucosa, and the intestinal absorptive function after transplantation in group 2 were similar to those of group 1. Conclusion. The effect of cold storage of swine small bowel with Lifor solution is similar to that of UW solution. It may provide additional rationale for further exploration of Lifor as an alternative preservation solution in small bowel transplantation.

Author: Mingxiao Guo, Chunlei Lu, Ying Gao, Haifeng Zhang, Dongfeng Chen, and Yousheng Li



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