PPARA Intron Polymorphism Associated with Power Performance in 30-s Anaerobic Wingate TestReportar como inadecuado

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To date, polymorphisms in several genes have been associated with a strength-power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength-power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene PPARA intron 7 G-C rs4253778; g.46630634G>C has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7 G-C polymorphism specifically on anaerobic power output in a group of 77 elite male Czech ice hockey players 18–36 y. We determined the relative peak power per body weight Pmax.kg−1 and relative peak power per fat free mass W.kg−1FFM during the 30-second Wingate Test WT30 on bicycle ergometer Monark 894E Peak bike, MONARK, Sweden. All WT30s were performed during the hockey season. Overall genotype frequencies were 50.6% GG homozygotes, 40.3% CG heterozygotes, and 9.1% CC homozygotes. We found statistically significant differences in Pmax.kg−1 and marginally significant differences in Pmax.kg−1FFM values in WT30 between carriers and non-carriers for C allele 14.6±0.2 vs. 13.9±0.3 W.kg−1 and 15.8±0.2 vs. 15.2±0.3 W.kg−1FFM, P = 0.036 and 0.12, respectively. Furthermore, Pmax.kg−1FFM strongly positively correlated with the body weight only in individuals with GG genotypes R = 0.55; p<0.001. Our results indicate that PPARA 7C carriers exhibited higher speed strength measures in WT30. We hypothesize that C allele carriers within the cohort of trained individuals may possess a metabolic advantage towards anaerobic metabolism.

Autor: Miroslav Petr , Petr Št‘astný, Ondřej Pecha, Michal Šteffl, Ondřej Šeda, Eva Kohlíková

Fuente: http://plos.srce.hr/


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