The Effects of Age and Cytomegalovirus on Markers of Inflammation and Lymphocyte Populations in Captive BaboonsReportar como inadecuado




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The human immune system undergoes age-related changes that can lead to increased disease susceptibility. Using the baboon as a model for human immune system aging, we examined age-related changes in relative and absolute numbers of T cell subpopulations, cytomegalovirus CMV titer and markers of inflammation. In addition, the effect of gender, social status and peer group on lymphocyte subpopulations was determined. Relative and absolute numbers of total lymphocytes CD3+, T helper cells CD4+, and cytotoxic T cells CD8+ increased with age. The proportion of naïve T cells CD45RA+ decreased, while the total number of cells negative for the co-stimulatory receptor, CD28 CD28- increased in an age-dependent manner. Furthermore, CMV titers were negatively correlated with the number of naive CD4+ cells. IL-6 and cortisol concentration were also negatively associated with T cell subpopulations. Additionally, socially dominant baboons exhibited decreases in naïve CD4+ and CD8+ cells by 65% and 52%, respectively compared to subordinate animals. These results suggest that factors such as CMV exposure and inflammation may contribute to the age-related decline in immune health and indicate that factors like social status should be considered when studying immunosenescence in animal models.



Autor: Erin L. Willis, Richard Eberle, Roman F. Wolf, Gary L. White, Dianne McFarlane

Fuente: http://plos.srce.hr/



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