Interleukin-1β-31C-T and -511T-C Polymorphisms Were Associated with Preeclampsia in Chinese Han PopulationReportar como inadecuado




Interleukin-1β-31C-T and -511T-C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

The purpose of our study is to investigate the relationship between IL-1β -31C-T rs1143627 and -511T-C rs16944 polymorphisms and the preeclampsia PE, and analyze the Linkage disequilibrium LD and haplotype frequency of the two polymorphism loci.

Methods

Polymorphisms at -31C-T and -511T-C of IL-1β were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism PCR- RFLP in 232 PE and 447 control subjects. Genotype and allele frequencies between case-control groups were compared by chi-squareX2 tests. Two-point LD and haplotype frequency analyses were done with the software Haploview4.2.

Results

Significant statistical differences were found between PE and control groups regarding genotype and allele frequencies of the two polymorphisms of IL-1β For IL-1β -31C-T: X2 = 11.478, P = 0.003; For IL-1β-511T-C: X2 = 9.687, P = 0.008. LD analysis revealed that the IL-1β -31C-T SNP was in high LD with the IL-1β-511C-T SNPD′ = 0.92, r2 = 0.79. Both CT and TC haplotypes showed significant differences between case and control groups. Only the plasma level of Prothrombin Time had a significantly statistical difference among TT, CT and CC groups of the preeclamptic two polymorphisms of IL-1β-31C-T and -511T-C for IL-1β-31C-T, F = 1.644, P = 0.01; F = 1.587, P = 0.016.

Conclusion

Our results revealed IL-1β was associated with the PE in Chinese Han population. The CT haplotype may increase the risk of PE, while haplotype TC could be considered as a protective haplotype of PE.



Autor: Xuefeng Wang , Fengli Jiang , Yu Liang, Lina Xu, Hongbo Li, Yali Liu, Shiguo Liu , Yuanhua Ye

Fuente: http://plos.srce.hr/



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