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Journal of Immunology Research - Volume 2015 2015, Article ID 591580, 6 pages -

Review ArticlePediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy

Received 30 September 2014; Revised 6 January 2015; Accepted 10 January 2015

Academic Editor: Antoni Torres

Copyright © 2015 Susanna Esposito and Nicola Principi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Applications of the heptavalent pneumococcal conjugate vaccine PCV7 in the pediatric immunization schedule have dramatically reduced the incidence of pneumococcal diseases in both vaccinated children and unvaccinated individuals of all ages. However, increased infections caused by non-PCV7 serotypes have been reported by several groups. To overcome this problem, new vaccines covering more serotypes including the emerging serotypes have been developed. The 13-valent pneumococcal conjugate vaccine PCV13 currently covers the 7 PCV7 serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F and 6 additional serotypes 1, 3, 5, 6A, 7F, and 19A. After the first year of PCV13 applications in the immunization schedule in young children, global evaluation studies demonstrated that PCV13 provided a wider coverage and more effective prevention than PCV7 against invasive pneumococcal diseases IPDs, mucosal pneumococcal diseases, and pneumococcal carriage. We reviewed the effects of PCV13 in the control of pneumococcal diseases in children based on previous studies.

Autor: Susanna Esposito and Nicola Principi



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