Prognostic factors for mortality in patients with bullous pemphigoid: a meta-analysisReportar como inadecuado

Prognostic factors for mortality in patients with bullous pemphigoid: a meta-analysis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Archives of Dermatological Research

, Volume 309, Issue 5, pp 335–347

First Online: 19 March 2017Received: 20 December 2016Revised: 03 March 2017Accepted: 08 March 2017DOI: 10.1007-s00403-017-1736-1

Cite this article as: Liu, YD., Wang, YH., Ye, YC. et al. Arch Dermatol Res 2017 309: 335. doi:10.1007-s00403-017-1736-1


Bullous pemphigoid BP is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed considerably various results. This meta-analysis aimed to quantitatively assess the association between several potential prognostic factors and risk of mortality in bullous pemphigoid. A comprehensive search was performed using Pubmed, Embase, and Cochrane Library. Cohort studies that assessed prognostic factors of BP mortality were included. Random-effects model was utilized to calculate the pooled hazard ratio HR. Publication bias was evaluated qualitatively by constructing a funnel plot and quantitatively by conducting Egger’s test. 14 studies were included comprising 2499 patients. Combined HRs suggested that advanced age HR 1.63, 95% CI 1.34–1.97, presence of circulating antibodies HR 1.77, 95% CI 1.20–2.62, concomitant dementia HR 2.01, 95% CI 1.22–3.33, and concomitant stroke HR 1.86, 95% CI 1.29–2.67 have an unfavorable impact on patient survival. Gender, disease extent, mucosal involvement, and indirect immunofluorescence result were not shown to be linked to mortality by our analysis. This study indicated that BP patients with older age, circulating antibodies, dementia, and stroke are at greater risk of mortality. Clinicians should be aware of this association and utilize this information in patient education and treatment process.

KeywordsBullous pemphigoid Autoimmune blistering disease Prognosis Mortality Survival Electronic supplementary materialThe online version of this article doi:10.1007-s00403-017-1736-1 contains supplementary material, which is available to authorized users.

Autor: Yi-Di Liu - Yan-Hong Wang - Yi-Cong Ye - Wen-Ling Zhao - Li Li


Documentos relacionados