Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of lifeReportar como inadecuado

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Quality of Life Research

, Volume 26, Issue 7, pp 1745–1759

First Online: 17 March 2017Accepted: 27 February 2017DOI: 10.1007-s11136-017-1539-z

Cite this article as: van Roekel, E.H., Bours, M.J.L., te Molder, M.E.M. et al. Qual Life Res 2017 26: 1745. doi:10.1007-s11136-017-1539-z


PurposeIncreased visceral adiposity visceral obesity and muscle wasting sarcopenia at colorectal cancer CRC diagnosis, quantified by computed tomography CT image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life HRQoL have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis.

MethodsA cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands 2002–2010. Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area cm; intermuscular adipose tissue area cm and mean muscle attenuation Hounsfield units as measures of muscle fat infiltration; and skeletal muscle index SMI, cm-m as measure of muscle mass and for determining sarcopenia.

ResultsParticipants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm standard deviation: 93.4 and SMI of 47.8 cm-m 7.2; 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences.

ConclusionsAlthough visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors.

KeywordsVisceral adiposity Muscle wasting Sarcopenia Health-related quality of life Colorectal cancer Electronic supplementary materialThe online version of this article doi:10.1007-s11136-017-1539-z contains supplementary material, which is available to authorized users.

Autor: Eline H. van Roekel - Martijn J. L. Bours - Malou E. M. te Molder - José J. L. Breedveld-Peters - Steven W. M. Ol


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