UV Spectrophotometric Method for the Estimation of Valacyclovir HCl in Tablet Dosage FormReportar como inadecuado




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E-Journal of Chemistry - Volume 6 2009, Issue 3, Pages 814-818



Department of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638 052, India

Department of Chemical Engineering, Alagappa College of Technology, Anna University, Guindy, Chennai-600 025, Tamilnadu, India

Received 26 February 2008; Revised 17 December 2008; Accepted 27 December 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of valacyclovir in bulk and tablet dosage form. Solution of valacyclovir in 0.1N HCl shows maximum absorbance at 255 nm. Beer’s law was obeyed in the concentration range of 5-25 mcg mL

with 1.0910x10

mol

cm

, the slope, intercept, correlation coefficient, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The percentages assay of valacyclovir HCl in tablet was 99.82%. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of valacyclovir in bulk and solid dosage form.





Autor: M. Ganesh, C. V. Narasimharao, A. Saravana Kumar, K. Kamalakannan, M. Vinoba, H. S. Mahajan, and T. Sivakumar

Fuente: https://www.hindawi.com/



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