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The Scientific World JournalVolume 2012 2012, Article ID 546171, 11 pages

Research Article

Medical Physics Department, University of Thessaly, Biopolis, 41110 Larissa, Greece

Neurosurgery Department, University of Thessaly, Biopolis, 41110 Larissa, Greece

Diagnostic Radiology Department, University of Thessaly, Biopolis, 41110 Larissa, Greece

Received 6 June 2012; Accepted 26 June 2012

Academic Editors: W. Hall, F. R. Verdun, and J. Zhou

Copyright © 2012 E. Kousi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the diagnostic value of 3T

H-MRS in grading cerebral gliomas using short and long echo times. Methods. 1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA-Cr, Cho-Cr, Cho-NAA, and mI-Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades. Results. Intratumoral Cho-Cr at both TEs and long TE Cho-NAA were significantly different between low and high grade gliomas. Peritumoral NAA-Cr of both TEs, as well as long TE Cho-Cr and Cho-NAA ratios, significantly differentiated the two tumor grades. Diagnostic sensitivity of peritumoral short TE NAA-Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho-Cr reached the highest levels of specificity and accuracy. Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE. Conclusion. An advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas. Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.





Autor: E. Kousi, I. Tsougos, E. Tsolaki, K. N. Fountas, K. Theodorou, I. Fezoulidis, E. Kapsalaki, and C. Kappas

Fuente: https://www.hindawi.com/



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