γδ T Cells Are Involved in Acute HIV Infection and Associated with AIDS ProgressionReportar como inadecuado




γδ T Cells Are Involved in Acute HIV Infection and Associated with AIDS Progression - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Early diagnosis is vital to HIV control. γδ T cells play critical roles in viral infections, but their activation in acute HIV infected patients and follow up to 18 months has not been described.

Methods

Changes in γδ T cells, including subsets, function and activation, in treated and untreated acutely HIV-infected patients n = 79 were compared by cytotoxicity assay and flow cytometry with healthy controls n = 21 at month 0, 6, 12 and 18.

Results

In acutely HIV-infected patients, Vδ1 cell proportion was elevated P = 0.027 with Vδ2 population reduced P = 0.002. Effector and central memory γδ T cell factions were decreased P = 0.006 and P = 0.001, respectively, while proportion of terminal γδ T cells increased P = 0.002. γδ T cell cytotoxicity was compromised over time. Fraction of IL-17-producing cells increased P = 0.008, and IFN-γ-producing cells were unaffected P = 0.115. Elevation of a microbial translocation marker, sCD14, was associated with γδ T cell activation P = 0.001, which increased in a time-dependent manner, correlating with CD4-CD8 T cell activation set-points and CD4 counts. Antiretroviral therapy did not affect these changes.

Conclusions

γδ T cell subpopulation and functions change significantly in acute HIV infection and over time. Early γδ T cell activation was associated with CD4-CD8 T cell activation set-points, which predict AIDS progression. Therefore, γδ T cell activation represents a potential surrogate marker of AIDS progression.



Autor: Zhen Li , Wei Li , Ning Li, Yanmei Jiao, Dexi Chen, Lianxian Cui, Yu Hu, Hao Wu , Wei He

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados