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Croatica Chemica Acta, Vol.71 No.3 October 1998. -

The essential role of metal ions in biology is stressed by structural investigations on two metalloenzymes: human carbonic anhydrase CA and Cu, Zn superoxide dismutase SOD. The X-ray structure of CA complex with histamine affords a satisfactory explanation of the mechanism of activation of CA. The high resolution 1.02 Å crystal structure of a mutant monomeric Cu, Zn superoxide dismutase gives relevant information on the mechanism of the catalytic activity of the native dimeric enzyme and on the reduced activity of the monomer.



Autor: Pierluigi Orioli - ; Department of Chemistry, University of Florence, Via Capponi 7, 50121 Florence, Italy

Fuente: http://hrcak.srce.hr/



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